Once daily solution achieves zero-to-trace cell severity

Article

Bromfenac ophthalmic solution 0.07% (Pro-Lensa, Bausch + Lomb) used once a day results in zero-to-trace (0–5 cells) cell severity in the anterior chamber following cataract surgery with implantation of a posterior chamber IOL, according to newly published research.

Bromfenac ophthalmic solution 0.07% (Pro-Lensa, Bausch + Lomb) used once a day results in zero-to-trace (0–5 cells) cell severity in the anterior chamber following cataract surgery with implantation of a posterior chamber IOL, according to newly published research. It also performed better than placebo in all outcome measures related to anterior chamber cell severity and inflammation, according to the US researchers, a group including representation from the drug’s manufacturer, Bausch + Lomb. They published their findings in Clinical Ophthalmology.

In two Phase III, double-masked, placebo-controlled, multicentre clinical trials, a total of 440 participants were randomly assigned to treatment with the bromfenac formulation or placebo. Participants were instructed to use once-daily dosing beginning one day before surgery, on the day of surgery and for 14 days after surgery. Follow-up occurred on days 1, 3, 8 and 15.

As early as the third day, researchers found, a significantly greater proportion of participants taking bromfenac had zero to five anterior chamber cells compared with the placebo group. This difference continued at day 8 and day 15, the latter day on which 80.2% of participants in the bromfenac and 47.2% of those in the placebo group met the criterion.

Overall anterior chamber cell scores and the summed ocular inflammation score were significantly lower in the bromfenac group compared with the placebo group at days 3, 8 and 15.

The authors note that, in April, based in part on the results of their clinical trial, the US Food and Drug Administration approved the formulation to treat postoperative inflammation and reduce ocular pain in those who have undergone cataract surgery. "In future clinical assessments, bromfenac 0.07% may be further evaluated in other ocular inflammatory disorders where [nonsteroidal anti-imflammatory drug] use may be potentially beneficial," they conclude.

To access the full study, click here.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Jay Chhablani, MD, shares late-breaking data from the ArMaDa trial, investigating gene therapy for Geographic Atrophy and dry age-related macular degeneration, at EURETINA
Editorial advisory board member Alexandra Miere, MD, PhD, speaks about the ACTOR and HERMES studies at the 2025 European Society of Retina Specialists (EURETINA) Congress
María Berrocal, MD, speaks about the Vit-Buckle Society symposium hosted at the 2025 European Society of Retina Specialists (EURETINA) annual meeting
© 2025 MJH Life Sciences

All rights reserved.