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Simultaneous IOPg, IOPcc measurements may provide significant data about patient groups.
Using non-contact (air-puff) technology, the auto tonometer simultaneously provides an IOP measurement similar to that obtained with the Goldmann applanation tonometry (GAT) and other current tonometers (referred to as Goldmann-correlated IOP or IOPg), as well as the IOPcc, a pressure that is independent of biomechanical artifacts such as corneal viscoelastic properties and thickness.
"It's a good instrument for somebody who's looking for a tonometer that provides [IOPcc] without having to worry about things like hysteresis or using correction algorithms for central corneal thickness (CCT)," said Nathan Radcliffe, MD, a glaucoma specialist and assistant professor of ophthalmology, Weill Cornell Medical College, New York Presbyterian Hospital, New York.
The combination of measurements provided by the auto tonometer could provide important information about two groups of patients, Dr. Radcliffe said. "One is patients with corneal disease, where you're worried that the corneal properties might interfere with pressure measurements, and the other is glaucoma patients, where corneal properties may be masking elevated [IOP]."
Additional risk factors
"In patients with [NTG], it is likely that we are underestimating the true IOP and that the higher pressure in these patients is at least partially masked by corneal biomechanical properties," Dr Radcliffe said.
He added that corneal hysteresis – one of the biomechanical properties accounted for by IOPcc – is a risk factor for glaucoma. Incorporating this component helps provide a more complete picture of the IOP values.
"This hasn't been evaluated yet," Dr Radcliffe said. "It's my hope that by using [IOPcc], not only will we be better able to identify patients with elevated pressure by unmasking the corneal properties, but we'll be better able to assess the effects of our therapy by measuring the pressure more accurately rather than relying on GAT, which measures pressure mixed in with confounding variables explained."
Using an ORA in his practice, Dr Radcliffe has found a high correlation between IOPg and traditional GAT.
"I would feel pretty comfortable if I had to move away from [GAT] to using the Goldmann-correlated pressure," he said. "I find the ability to know the IOPcc a very important part of my practice. I'm imagining a day when I stop checking GAT and just use IOPg and IOPcc to follow my patients.
"There are other advantages to using a non-contact system," he continued. "For example, not having to anesthetize the cornea or apply fluorescein to test the pressure. Also, research has shown that many Goldmann tonometers are improperly calibrated. Not only are we using an instrument that even on its best days has flaws, but most of us aren't even keeping it calibrated properly."
Interest in corneal biomechanics
There is tremendous interest in corneal biomechanics and its effect on ocular diseases, Dr. Radcliffe added. "It's only a matter of time before we're seeing more [IOPcc] measurements in clinical practice."
In addition to its function in measuring the IOP of glaucoma suspects and patients, the auto tonometer has other potential applications. It could be a valuable tool for measuring IOP in patients who have undergone keratorefractive procedures, which often affect CCT and biomechanics and contribute to inaccuracies in measurements performed with traditional GAT, Dr Radcliffe said.
"There are a lot of surprises when you start looking at patients with IOPcc and you realize that adjusting pressure by corneal thickness can be misleading in both the magnitude and in the direction of the correction," he concluded.