New Retaane trial kicks off

Article

The Anecortave Acetate Risk Reduction Trial (AARRT) has met its patient enrollment requirement of almost 2,600 individuals who are at high risk for developing choroidal neovascularization (CNV) or advanced age-related macular degeneration (AMD) over time, reported Jason Slakter, MD, of the Vitreous-Retina-Macular Consultants of New York, USA at the 2006 meeting of the AAO in Las Vegas.

The Anecortave Acetate Risk Reduction Trial (AARRT) has met its patient enrollment requirement of almost 2,600 individuals who are at high risk for developing choroidal neovascularization (CNV) or advanced age-related macular degeneration (AMD) over time, reported Jason Slakter, MD, of the Vitreous-Retina-Macular Consultants of New York, USA, at the 2006 meeting of the AAO in Las Vegas.

"Anecortave acetate (Retaane, Alcon Laboratories) was chosen for this trial based on preclinical data that suggest that this molecule inhibits new blood vessel formation by striking multiple targets in the angiogenic cascade," Dr Slakter said. "In addition, the drug has an excellent safety profile making it ideal for chronic, long-term suppressant therapy".

The drug is administered every six months, outside the eye. Two concurrent clinical trials on anecortave acetate are now ongoing with patients in one study receiving a 15 mg dose or sham administration and the other set of patients receiving a 30 mg dose or sham. The trials will follow patients for four years.

"Interestingly, 86% were using some type of vitamins. However, only about 50% of the patients were using the AREDS formulation," Dr Slakter noted. At baseline the average visual acuity in the study eye was 20/25 and in the non-study eye it was 20/200. Forty-six percent of patients had active disease in the non-study eye at baseline and 92% had subfoveal involvement.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Alfredo Sadun, MD, PhD, chief of Ophthalmology at the Doheny Eye Institute, University of California Los Angeles, shared exciting new research with the Eye Care Network during the Association for Research in Vision and Ophthalmology (ARVO) meeting on the subject of Leber hereditary optic neuropathy (LHON).
At this year's Association for Research in Vision and Ophthalmology (ARVO) meeting in Salt Lake City, Utah, Nitish Mehta, MD, shared highlights from his research documenting real-world results of aflibercept 8 mg for patients with diabetic macular oedema.
ARVO 2025: Anat Loewenstein, MD, shares data from herself and her colleagues on meeting needs of patients with diabetic retinopathy
At the American Society of Cataract and Refractive Surgeons annual meeting, Sheng Lim, MD, FRCOphth discusses the benefit of endoscopic cyclophotocoagulation for patients with primary open angle glaucoma and cataracts in the CONCEPT study
A photo of Seville, Spain, with the Congress on Controversies in Ophthalmology logo superimposed on it. Image credit: ©francovolpato – stock.adobe.com; logo courtesy COPHy
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center, discusses the Congress on Controversies in Ophthalmology (COPHy)
(Image credit: Ophthalmology Times Europe) AGS 2025: Clemens Strohmaier, PhD, on improving aqueous humour outflow following excimer laser trabeculostomy
3 experts are featured in this series.
Anat Loewenstein, MD, speaks about the 22nd Annual Angiogenesis, Exudation, and Degeneration Meeting in February 2025 and shares her global forecast for AI-driven home OCT
3 experts are featured in this series.
Related Content
© 2025 MJH Life Sciences

All rights reserved.