New research data reflect patient satisfaction following faricimab treat-and-extend regimen


A retrospective observational study shows BCVA was maintained after 6 months for patients with neovascular AMD

A patient covers her eye to perform a Snellen chart test as the optometrist looks on. Image credit: ©megaflopp –

Study results showed that the best-corrected visual acuity was maintained 6 months after the patients were switched to the faricimab treat-and-extend regimen Image credit: ©megaflopp –

A Japanese study found that switching to faricimab (Vabysmo, Genentech) treatment using a treat-and-extend (TAE) regimen seems to maintain the best-corrected visual acuity (BCVA) and extend the injection interval in patients with neovascular age-related macular degeneration (nAMD), resulting in enhanced satisfaction 6 months after patients were switched.1 Taiichi Hikichi, MD, who is in private practice in Sapporo, Japan, reported his findings in the Japanese Journal of Ophthalmology.

Dr Hikichi conducted a retrospective observational study of 48 consecutive eyes of 48 patients with nAMD who were switched to faricimab and followed for 6 months while they were on a TAE regimen. At the 6-month time point, the patients completed the Macular Disease Treatment Satisfaction Questionnaire (MacTSQ).

The results showed that the BCVA was maintained 6 months after the patients were switched to the faricimab TAE regimen. In addition, the mean central foveal thickness decreased significantly (p < 0.001) at 6 months compared to the time at which patients started on faricimab from 372 ± 20 μm to 272 ± 14 μm.

The treatment interval following the switch was 10.45 ± 0.44 weeks, which differed significantly (p = 0.002) from the treatment interval of 6.72 ± 0.34 weeks at the time of the switch.

Dr Hikichi also reported that the MacTSQ total score of 58.8 ± 1.7 in eyes with a BCVA of 20/40 and better 6 months after the switch was significantly (p < 0.001). higher compared to that in eyes with a BCVA worse than 20/40 (48.2 ± 1.5). The MacTSQ total score of 56.8 ± 1.8 in eyes in which a 4-week extension of the injection interval was achieved was significantly higher than the 49.5 ± 1.9 in eyes without (p < 0.001).

He concluded that switching to faricimab administered using a TAE regimen seems to maintain the BCVA and extend the injection interval in patients with nAMD, resulting in enhanced patient satisfaction.


1. Hikichi T. Investigation of satisfaction with short-term outcomes after switching to faricimab to treat neovascular age-related macular degeneration. Jpn J Ophthalmol. 2023;67:652-6;
Related Videos
Ramin Tadayoni, MD, speaks with Sheryl Stevenson
Jennifer I. Lim, MD, FARVO, FASRS, Director of Retina Service, University of Illinois at Chicago
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center
Carl D. Regillo, MD, FACS, FASRS, Chief of Retina Service, Wills Eye Hospital, Philadelphia, PA
Arshad Khanani, MD, MA FASRS, on a virtual call
Diana Do, MD, Professor of Ophthalmology, Byers Eye Institute, Stanford University, discusses the PHOTON study results as presented AAO
Penny A Asbell, MD, FACS speaks at the 2023 AAO meeting
© 2024 MJH Life Sciences

All rights reserved.