Measuring RNFL thickness

Article

Operator-dependent centring and automatic centring retinal nerve fibre layer (RNFL) thickness measurement patterns (RNFL3.45 and NHM4) have been shown to be in good agreement.

Operator-dependent centring and automatic centring retinal nerve fibre layer (RNFL) thickness measurement patterns (RNFL3.45 and NHM4) have been shown to be in good agreement, according to a study published in Clinical and Experimental Ophthalmology.

Dr Shuning Li et al., Beijing Ophthalmology and Visual Science Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, China, conducted a cross-sectional observational study on 153 eyes of 149 patients. RNFL3.45 and NHM4 were used to measure retinal nerve fibre layer thickness three times daily. The outcome measures were Student's paired t-test, intra-class correlation coefficient, and coefficient of variation, test–retest viability, Pearson's correlation coefficient and Bland–Altman analysis of RNFL thickness measurements.

Paired t-testing demonstrated that the difference between RNFL3.45 and NHM4 measurements were statistically significant in the severe glaucoma group. The Pearson's correlation test revealed a strong correlation of the mean RNFL.

Bland–Altman plots revealed that the differences between RNFL3.45 and NHM4 were larger at thinner RNFL values, but smaller at thicker RNFL values. The intra-class correlation coefficient for RNFL3.45 in control patients and glaucoma patients was 0.990 and 0.997, respectively. For NHM4 the intra-class correlation coefficient was 0.989 and 0.995 for the control patients and glaucoma patients, respectively.

RNFL3.45 and NHM4 are both sufficient methods for RNFL thickness.

Related Videos
Ramin Tadayoni, MD, speaks with Sheryl Stevenson
Jennifer I. Lim, MD, FARVO, FASRS, Director of Retina Service, University of Illinois at Chicago
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center
Carl D. Regillo, MD, FACS, FASRS, Chief of Retina Service, Wills Eye Hospital, Philadelphia, PA
Arshad Khanani, MD, MA FASRS, on a virtual call
Penny A Asbell, MD, FACS speaks at the 2023 AAO meeting
© 2024 MJH Life Sciences

All rights reserved.