HSK disease cause greater HOAs

Article

Eyes with a history of herpes simplex keratitis (HSK) have significantly greater higher order aberrations (HOAs) than eyes with no past history of the disease, according to a paper.

Eyes with a history of herpes simplex keratitis (HSK) have significantly greater higher order aberrations (HOAs) than eyes with no past history of the disease, according to a paper.

Professor Marc Labetoulle et al., Service d'Ophtalmologie, Hopital Bicêtre, APHP, Université Paris, France, enrolled 15 patients with a history of recurrent unilateral HSK and normal Snellen visual acuity. The eyes were statically compared with normal fellow eyes (control group) and HOA, modulation transfer function (MTF) and Strehl ratio were measured using the OPD-SCAN II aberrometer. The measurements were performed at least 3 months after the last case of herpes.

The HSK group presented with significantly higher total HOA, trefoil and tetrafoil, compared to the control group. The HSK group also had significantly lower MTF and Strehl ratio compared to the control group. Eyes with corneal opacities in the HSK group tended to have greater optical aberrations than eyes with clear cornea.

There were greater HOAs in the eyes with a HSK history and this could explain some of the visual complaints of HSK. This includes decrease in contrast quality or reduced colour perception.

Please visit the British Journal of Ophthalmology to read the abstract.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Omer Trivizki, MD, MBA, a retina specialist from Tel Aviv Medical Center, speaks about VOY-101, a Novel, Complement-Modulating Gene Therapy for Geographic Atrophy at the American Society of Retina Specialists (ASRS) Annual Meeting
João Pedro Marques, MD, MSc, PhD discusses a retrospective study of 800 patients with inherited retinal diseases during the American Society of Retina Specialists (ASRS) annual meeting
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
© 2025 MJH Life Sciences

All rights reserved.