Focal LC defects correlate with occurrence of neuroretinal rim and visual field loss

Article

Focal lamina cribrosa (LC) occurs in conjunction with neuroretinal rim and visual field loss.

Focal lamina cribrosa (LC) occurs in conjunction with neuroretinal rim and visual field loss, claims a study in the Archives of Ophthalmology.

Dr Saman Kiumehr et al., Department of Ophthalmology, New York University School of Medicine, New York, USA, compiled a study on 92 eyes of 46 healthy participants and 45 eyes of 31 participants with glaucoma.

All subjects underwent serial horizontal and vertical enhanced depth imaging of the optic nerve head with optical coherence tomography (OCT). Anterior laminar surface irregularity constituted as focal LC defects and spatial consistency was assessed among focal LC defects, neuroretinal rim thinning/notching and visual field defects.

Although there were no LC defects in the healthy eyes there were 98 focal LC defects with various patterns of severity identified in 34 glaucomatous eyes. In the remaining 11 glaucomatous eyes, seven presented with a deeply excavated optic disc.

In the eyes with LC defects 11 had an acquired pit of the optic nerve and the remaining defects occurred due to neuroretinal rim thinning/notching. The majority of defects occurred in the inferior/inferotemporal far periphery of the LC.

Greater sensitivity loss was found in the eyes with focal LC defects limited to the inferior half of the optic disc. Focal loss of laminar beams in glaucoma could cause an acquired pit of the optic nerve.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Rayaz Malik, MBChB, PhD, a professor of medicine at Weill Cornell Medicine - Qatar, spoke with Ophthalmology Times Europe about his presentation. It's titled "An eye on neurodegenerative diseases: Challenging the dogma" at the International SPECTRALIS Sympsoium. In conversation with Hattie Hayes, Ophthalmology Times Europe
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Rayaz Malik, MBChB, PhD, shares his presentation, titled An eye on neurodegenerative diseases: Challenging the dogma, at this year's International SPECTRALIS Symposium
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
© 2025 MJH Life Sciences

All rights reserved.