Epithelium removal not necessary for collagen cross-linking

Article

Corneal collagen cross-linking with riboflavin, without removing the epithelium, is both safe and effective.

Corneal collagen cross-linking with riboflavin, without removing the epithelium, is both safe and effective, according to Roberto Pinelli, ILMO, Brescia, Italy.

Dr Pinelli examined two groups of five keratoconic patients. Group A was treated monocularly without removing the epithelium and Group B was treated after epithelial removal. Custom-made riboflavin eye-drops were applied to the cornea and activated by UV-A.

Dr Pinelli noted no significant differences between the two groups postoperatively. The 30 eyes in Group A, at 18 months follow-up, showed a mean K reduction of 0.83 D, higher K reduction in the 3 mm central zone, a mean uncorrected visual acuity (UCVA) improvement of 1.3 lines, a mean best spectacle corrected visual acuity (BSCVA) and an increase in central pachymetry. Furthermore, keratoconus progression was halted in all eyes.

These results demonstrate that it is not necessary to remove the epithelium in order for riboflavin to effectively penetrate the cornea.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Jay Chhablani, MD, shares late-breaking data from the ArMaDa trial, investigating gene therapy for Geographic Atrophy and dry age-related macular degeneration, at EURETINA
Editorial advisory board member Alexandra Miere, MD, PhD, speaks about the ACTOR and HERMES studies at the 2025 European Society of Retina Specialists (EURETINA) Congress
María Berrocal, MD, speaks about the Vit-Buckle Society symposium hosted at the 2025 European Society of Retina Specialists (EURETINA) annual meeting
© 2025 MJH Life Sciences

All rights reserved.