Continuous IOP monitoring

Article

Investigating tolerability of a diagnostic device in healthy and glaucomatous patients

"The role of IOP fluctuation as an independent predictive factor for glaucoma progression is still controversial,"6–10 she added. "Goldmann applanation tonometry (GAT) has been the most widely established indirect method for measuring IOP for many decades and is the gold standard."11–14

"We tested the first model for use in humans for the first time in healthy subjects and in glaucoma patients with the primary objective to investigate tolerability and side effects of the device during and after a 24-hour IOP monitoring period," explained Dr Lorenz. Taking both healthy subjects and glaucoma patients and excluding anyone who had worn contact lenses before, the team placed one sensor in each patient's test eye and performed examinations both before and after the 24 hour wearing period.

"To evaluate the level of discomfort of the device in the study eye at 24 hours, a visual analogue scale (VAS) was presented to the subject. VAS for each subject was scored between 0 and 100 mm, the number corresponding to the distance in millimetres of the subject's mark on the VAS line from the left end. Secondary endpoints included best corrected visual acuity (BCVA), pachymetry, epithelial defects, conjunctival erythema and corneal topography," she said. "Additionally, subjects were asked to fill in a diary which was collected at the end of the study."

A test was also performed initially to ensure that healthy and glaucoma patients could be analysed together, as the device had never been formally tested in healthy subjects before. Dr Lorenz explained that if the glaucoma patients had demonstrated severe discomfort in this trial there would have been some difficulty in proving that it was not significantly associated with ocular surface disease, therefore, healthy subjects were required to be used as controls. "However, contrary to our expectations, no significant differences between the two groups could be demonstrated and both groups were combined for analysis," she asserted.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Rayaz Malik, MBChB, PhD, a professor of medicine at Weill Cornell Medicine - Qatar, spoke with Ophthalmology Times Europe about his presentation. It's titled "An eye on neurodegenerative diseases: Challenging the dogma" at the International SPECTRALIS Sympsoium. In conversation with Hattie Hayes, Ophthalmology Times Europe
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Rayaz Malik, MBChB, PhD, shares his presentation, titled An eye on neurodegenerative diseases: Challenging the dogma, at this year's International SPECTRALIS Symposium
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
© 2025 MJH Life Sciences

All rights reserved.