
Carbon monoxide lowers IOP
CORM-3, a water-soluble carbon monoxide-releasing molecule, is associated with a intraocular pressure (IOP) lowering in animal models of ocular hypertension, concluded a study published in the January issue of the British Journal of Ophthalmology.
CORM-3, a water-soluble carbon monoxide-releasing molecule, is associated with intraocular pressure (IOP) lowering in animal models of ocular hypertension, concluded a study published in the January issue of the British Journal of Ophthalmology.
In both trial arms, administration of CORM-3 was associated with a reduction in IOP; dosage amount was positively correlated with the amount of IOP reduction. The control subjects experienced no IOP reduction.
The researchers therefore concluded that CORM-3 is associated with a reduction of IOP in two separate animal models of induced ocular hypertension. This correlation between carbon monoxide modulation and IOP has been established by previous studies.