Avastin is non-toxic

June 4, 2008

Avastin (bevacizumab) does not exert any toxic effects on the retina and its function, according to a study published in the January issue of Retina journal.

Avastin (bevacizumab) does not exert any toxic effects on the retina and its function, according to a study published in the January issue of Retina journal.

A team led by Professor Peter Heidushka of the University Eye Hospital Tuebingen, Tuebingen, Germany, examined the retinal function of wild-type mice that received an intravitreal injection of Avastin.

Electroretinography (ERG) was performed on four different groups of mice: group 1) mice were injected intravitreally with BSS; group 2) mice received injections of a vehicle solution; group 3) mice were injected with Avastin solution; group 4) mice received sham surgery. ERG was performed before treatment and one, four, 12, and 25 days post treatment.

ERG parameters were similar in all four groups; no difference could be seen between eyes injected with Avastin and those receiving the vehicle solution. Bevacizumab immunoreactivity was present in the retina 30 mins after Avastin injection, but this was no longer detectable 25 days later.

The authors therefore concluded that Avastin does not have any harmful effects on the retina or its function; it penetrates the retina quickly and safely after injection.

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