According to a report published in the September 5th issue of the Journal of Biological Chemistry, two processes in the retina, which in combination contribute to age-related macular degeneration (AMD), can be disrupted by antioxidants.
According to a report published in the September 5th issue of the Journal of Biological Chemistry, two processes in the retina, which in combination contribute to age-related macular degeneration (AMD), can be disrupted by antioxidants.
Heidi Vollmer-Snarr from Brigham Young University, Utah and colleagues from the Dyson Research Institute and Weill Medical College, Cornell University, New York, US found that the age lipid A2E and mitochondrial dysfunction work together to impair phagocytosis of retinal pigment epithelial (RPE) cells.
The build up of the compound A2E speeds up the death of RPE cells, which are not then replaced when they die. However, experiments performed with the cells from rats, cows and humans shows that antioxidants could completely counter such damage.
The implications of this study, according to the researchers, is that people at risk of developing AMD could help prevent the disease by consuming antioxidants.
AAO 2024: Detail outlined for Artificial Intelligence Innovation Center at Wilmer Eye Institute
October 24th 2024During a conversation at the American Academy of Ophthalmology annual meeting in Chicago, T.Y. Alvin Liu, MD, discussed plans for the James P. Gills Jr, MD, & Heather Gills Artificial Intelligence Innovation Center at the Wilmer Eye Institute at Johns Hopkins Medicine.