Antioxidants join the fight against AMD

Article

According to a report published in the September 5th issue of the Journal of Biological Chemistry, two processes in the retina, which in combination contribute to age-related macular degeneration (AMD), can be disrupted by antioxidants.

According to a report published in the September 5th issue of the Journal of Biological Chemistry, two processes in the retina, which in combination contribute to age-related macular degeneration (AMD), can be disrupted by antioxidants.

Heidi Vollmer-Snarr from Brigham Young University, Utah and colleagues from the Dyson Research Institute and Weill Medical College, Cornell University, New York, US found that the age lipid A2E and mitochondrial dysfunction work together to impair phagocytosis of retinal pigment epithelial (RPE) cells.

The build up of the compound A2E speeds up the death of RPE cells, which are not then replaced when they die. However, experiments performed with the cells from rats, cows and humans shows that antioxidants could completely counter such damage.

The implications of this study, according to the researchers, is that people at risk of developing AMD could help prevent the disease by consuming antioxidants.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Rayaz Malik, MBChB, PhD, a professor of medicine at Weill Cornell Medicine - Qatar, spoke with Ophthalmology Times Europe about his presentation. It's titled "An eye on neurodegenerative diseases: Challenging the dogma" at the International SPECTRALIS Sympsoium. In conversation with Hattie Hayes, Ophthalmology Times Europe
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Rayaz Malik, MBChB, PhD, shares his presentation, titled An eye on neurodegenerative diseases: Challenging the dogma, at this year's International SPECTRALIS Symposium
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
Related Content
© 2025 MJH Life Sciences

All rights reserved.